Canadian Pharmacy fen-phen recall follows U.S. lead

Ottawa – Popular diet drugs fenfluramine and dexfenfluramine have been withdrawn from the Canadian market after disturbing new evidence suggested they may cause valvular heart disease. The move a voluntary recall of the drugs by the companies according to the Health Protection Branch (HPB) of Health Canada here follows similar action by the American Food and Drug Administration (FDA) after new information on the complications of these drugs was made available. In July researchers at the Mayo Clinic Rochester Minn. reported 24 cases of rare valvular disease in women who took combination therapy of fenfluramine with phentermine widely used off-label combination known as “fen-phen.” The FDA alerted doctors that it had received nine additional reports of the same type and requested all health-care professionals to report any such cases to the agency’s MedWatch program or to the manufacturers. Subsequently they received 66 additional reports of heart valve disease associated mainly with the fen-phen combination but also with fenfluramine and dexfenfluramine used alone. All of these cases had been symptomatic. (more…)

April 27th, 2015 - Posted in Medicines, Weight Loss | | Comments Off